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PI, Family, Clan or Protein ID
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Year
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Design of small-molecule Inhibitors
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Total records: 16
PI, Family, Clan or Protein ID
Authors
Title
Source
Year
PubMed
DOI
Category
I03.009
Telang,M.A., Giri,A.P., Pyati,P.S., Gupta,V.S., Tegeder,M. & Franceschi,V.R.
Winged bean chymotrypsin inhibitors retard growth of Helicoverpa armigera
Gene (2009) 431, 80-85.
2009
PubMed
DOI
Substrate specificity
I03.009
Dasgupta,J., Khamrui,S., Dattagupta,J.K. & Sen,U.
Spacer Asn determines the fate of Kunitz (STI) inhibitors, as revealed by structural and biochemical studies on WCI mutants
Biochemistry (2006) 45, 6783-6792.
2006
PubMed
DOI
Mutation, allelic variant or polymorphism
I03.009
Khamrui,S., Dasgupta,J., Dattagupta,J.K. & Sen,U.
Single mutation at P1 of a chymotrypsin inhibitor changes it to a trypsin inhibitor: X-ray structural (2.15 A) and biochemical basis
Biochim Biophys Acta (2005) 1752, 65-72.
2005
PubMed
DOI
Three-dimensional Structure
I03.009
Ravichandran,S., Dasgupta,J., Chakrabarti,C., Ghosh,S., Singh,M. & Dattagupta,J.K.
The role of Asn14 in the stability and conformation of the reactive-site loop of winged bean chymotrypsin inhibitor: crystal structures of two point mutants Asn14 - >Lys and Asn14 - >Asp
Protein Eng (2001) 14, 349-357.
2001
PubMed
Mutation, allelic variant or polymorphism
I03.009
Ravichandran,S., Sen,U., Chakrabarti,C. & Dattagupta,J.K.
Cryocrystallography of a Kunitz-type serine protease inhibitor: the 90 K structure of winged bean chymotrypsin inhibitor (WCI) at 2.13 A resolution
Acta Crystallogr D Biol Crystallogr (1999) 55, 1814-1821.
1999
PubMed
DOI
Three-dimensional Structure
I03.009
Dattagupta,J.K., Podder,A., Chakrabarti,C., Sen,U., Mukhopadhyay,D., Dutta,S.K. & Singh,M.
Refined crystal structure (2.3 A) of a double-headed winged bean alpha-chymotrypsin inhibitor and location of its second reactive site
Proteins (1999) 35, 321-331.
1999
PubMed
DOI
Three-dimensional Structure
I03.009
Ghosh,S. & Singh,M.
cDNA cloning, expression, and rapid purification of a Kunitz-type winged bean chymotrypsin inhibitor
Protein Expr Purif (1997) 10, 100-106.
1997
PubMed
DOI
Gene Expression
I03.009
Habu,Y., Peyachoknagul,S., Sakata,Y., Fukasawa,K. & Ohno,T.
Evolution of a multigene family that encodes the Kunitz chymotrypsin inhibitor in winged bean: a possible intermediate in the generation of a new gene with a distinct pattern of expression
Mol Gen Genet (1997) 254, 73-80.
1997
PubMed
DOI
Review
I03.009
Sakata,Y., Chiba,Y., Fukushima,H., Matsubara,N., Habu,Y., Naito,S. & Ohno,T.
The RY sequence is necessary but not sufficient for the transcription activation of a winged bean chymotrypsin inhibitor gene in developing seeds
Plant Mol Biol (1997) 34, 191-197.
1997
PubMed
DOI
Gene Expression
I03.009
Habu,Y., Fukushima,H., Sakata,Y., Abe,H. & Funada,R.
A gene encoding a major Kunitz proteinase inhibitor of storage organs of winged bean is also expressed in the phloem of stems
Plant Mol Biol (1996) 32, 1209-1213.
1996
PubMed
Gene Expression
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